Article

Gene transcription and chromatin packing domains form a self- organizing system

2026-03-17

Abstract excerpt

The human genome organizes into several thousand chromatin packing domains that couple euchromatin and heterochromatin into unified nanoscale volumes. Prior work suggested these domains form by transcriptionally driven loops that guide packing domain assembly. Here, we study the process of transcriptionally driven domain formation and maintenance. By pairing auxin-inducible degron technology with nanoscopic imagin...

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Literature Corpus work: bd6e6bc9-bf5b-5364-bd8d-9ac2c3a408cc
DOI: 10.64898/2026.03.15.711889

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