Article

Perturb-tracing enables high-content screening of multiscale 3D genome regulators

2023-02-01

Abstract excerpt

Three-dimensional (3D) genome organization becomes altered during development, aging, and disease 1–23 , but the factors regulating chromatin topology are incompletely understood and currently no technology can efficiently screen for new regulators of multiscale chromatin organization. Here, we developed an image-based high-content screening platform (Perturb-tracing) that combines pooled CRISPR screen, a new cel...

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Literature Corpus work: 80cead2f-4174-58ff-9118-e996577d3a89
DOI: 10.1101/2023.01.31.525983

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