Article

L1 and B1 repeats blueprint the spatial organization of chromatin

2019-10-13

Abstract excerpt

<h4>SUMMARY</h4> Despite extensive mapping of three-dimensional (3D) chromatin structures, the basic principles underlying genome folding remain unknown. Here, we report a fundamental role for L1 and B1 retrotransposons in shaping the macroscopic 3D genome structure. Homotypic clustering of B1 and L1 repeats in the nuclear interior or at the nuclear and nucleolar peripheries, respectively, segregates the genome i...

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Literature Corpus work: dab7c677-7cdb-5cbb-a911-d486366c4b3a
DOI: 10.1101/802173

Open publication

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