Article

Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and Transcription

2020-07-16

Abstract excerpt

Despite the long-observed correlation between H3K9me3, chromatin architecture and transcriptional repression, how H3K9me3 regulates genome higher-order organization and transcriptional activity in living cells remains unclear. Here we develop EpiGo ( E pigenetic p erturbation i nduced G enome o rganization)-KRAB to introduce H3K9me3 at hundreds of loci spanning megabases on human chromosome 19 and simultaneou...

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Literature Corpus work: e9f6db85-cee5-5e59-a030-862c3d9e7598
DOI: 10.1101/2020.07.15.204719

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