Article

CRISPR-FOIL: A Programmable CRISPR Tool to Engineer and Illuminate Chromatin Folding in Live Human Cells

2026-08-11

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin organization plays a critical role in regulating gene expression. Chromatin compaction represses gene expression by physically restricting the access of the transcriptional machinery to DNA, while spatial proximity between enhancers and promoters, often mediated by chromatin loops, is essential for gene activation. To investigate the regulatory mechanisms underlying loop formation and...

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Literature Corpus work: 359f736c-b136-5efd-8b9a-e241f6e6093e
DOI: 10.64898/2026.08.09.743771

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