Article

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

2024-09-23

Abstract excerpt

<h4>ABSTRACT</h4> The CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown. Here we show that the CHAMP complex promotes heterochromatin assembly at multiple chromosomal sites, including centromeres and telomeres, and promotes homology-directed repair (HDR)...

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Literature Corpus work: 96a27ec9-a65b-52fd-905a-cafd62c7af23
DOI: 10.1101/2024.09.23.614480

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