Article

CRISPR-based multi-locus real-time tracking reveals single chromosome dynamics and compaction

2022-02-01

Abstract excerpt

In eukaryotic nuclei, individual chromosomes occupy discrete three-dimensional spaces with little overlap. Dynamic chromatin organization instantly influences DNA accessibility through modulating local macromolecular density and interactions, driving changes in transcription activities. Chromatin anchoring to nuclear landmarks often leads to massive reorganization and motion changes. Chromatin dynamics has been re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cad3b7f9-e9d8-5a81-b49b-3dcf28db60c3
DOI: 10.1101/2022.02.01.478681

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR-based multi-locus real-time tracking reveals single chromosome dynamics and compactionDOI 10.1101/2022.02.01.478681Read

Interrogation of the Dynamic Properties of Higher-Order Heterochromatin Using CRISPR/dCas9Semantic proximity Read

Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genesSemantic proximity Read

Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replicationSemantic proximity Read

Perturb-tracing enables high-content screening of multiscale 3D genome regulatorsSemantic proximity Read

Differential Regulation of Large-scale Chromosome Conformations in Osteoblasts and OsteosarcomaSemantic proximity Read

Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of MagnitudeSemantic proximity Read

Walking along chromosomes with super-resolution imaging, contact maps, and integrative modelingSemantic proximity Read

Uncovering High-Resolution Organization of Genomic Loci using Experimentally Informed Polymer ModelSemantic proximity Read

Genome Compartmentalization with Nuclear Landmarks: Random yet PreciseSemantic proximity Read

Minimalistic 3D Chromatin Models: Sparse Interactions in Single Cells Drive the Chromatin Fold and Form Many-Body UnitsSemantic proximity Read

CRISPR-FOIL: A Programmable CRISPR Tool to Engineer and Illuminate Chromatin Folding in Live Human CellsSemantic proximity Read

Spatiotemporal allele organization by allele-specific CRISPR live-cell imaging (SNP-CLING).Semantic proximity Read