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The impact of chromatin dynamics on Cas9-mediated genome editing in human cells

2016-08-25

Abstract excerpt

<h4>ABSTRACT</h4> In order to efficiently edit eukaryotic genomes, it is critical to test the impact of chromatin dynamics on CRISPR/Cas9 function and develop strategies to adapt the system to eukaryotic contexts. So far, research has extensively characterized the relationship between the CRISPR endonuclease Cas9 and the composition of the RNADNA duplex that mediates the system’s precision. Evidence suggests that...

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Literature Corpus work
cbe1f995-6404-5885-beac-f9ef672dc421
DOI
10.1101/071464
Open publication

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