Article
Immortalization and transformation of primary cells mediated by engineered ecDNAs
2023-06-26
Abstract excerpt
<h4>ABSTRACT</h4> Focal gene amplifications are among the most common cancer-associated mutations, but their evolution and contribution to tumorigenesis have proven challenging to recapitulate in primary cells and model organisms. Here we describe a general approach to engineer large (>1 Mbp) focal amplifications mediated by extrachromosomal circular DNAs (ecDNAs, also known as “double minutes”) in a spatiotempor...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 6216378c-944c-5e61-bd6e-a987145d4d4b
- DOI
- 10.1101/2023.06.25.546239