Dynamic optimization of extrachromosomal DNA copy number drives tumour evolution

Abstract excerpt

<h4>ABSTRACT</h4> Extrachromosomal DNA (ecDNA) is common in human cancers and is associated with poor clinical outcomes, yet how ecDNA-driven genetic heterogeneity is translated into functional heterogeneity remains unclear. Using single-cell multiomics sequencing and multiplexed IF-FISH, we show that asymmetric inheritance of ecDNA generates copy number heterogeneity that propagates to gene expression programs,...

Topics

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• Computer Simulation
• Datasets as Topic
• DNA
• DNA Copy Number Variations
• Genetic Heterogeneity
• Mutation
• Neoplasms
• Neuroblastoma Research and Treatments

Identifiers and source

Literature Corpus work

f8358d32-9808-5f57-800a-069d96fe5695

DOI

10.64898/2026.03.20.713026