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Extrachromosomal circular DNA (eccDNA): an emerging star in cancer

26 Jul 2022

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists widely in nature and is independent of chromosomes. EccDNA has attracted the attention of researchers due to its broad, random distribution, complex biogenesis and tumor-relevant functions. EccDNA can carry complete gene information, especially the oncogenic driver genes that are often carried in tumors, with increased copy...

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PMID: 35883211
DOI: 10.1186/s40364-022-00399-9

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