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Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

2 Oct 2022

Abstract excerpt

Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of somatic rearrangements, contributing to genomic remodeling through chimeric circularization and reintegration of circular DNA into the linear genome. In addition, the origin of eccDNA is considered to be...

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PMID: 36184613
DOI: 10.1038/s41392-022-01176-8

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