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Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potential

25 May 2025

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) has emerged as a dynamic and versatile genomic element with key roles in physiological regulation and disease pathology. This review synthesizes current knowledge on eccDNA, covering its classification, biogenesis, detection methods, biological functions, and clinical implications. Once considered rare anomalies, eccDNAs are now recognized as major drivers of oncogene...

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PMID: 40521196
DOI: 10.7150/thno.111765

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