Article

Pervasive lesion segregation shapes cancer genome evolution

2019-12-08

Abstract excerpt

<h4>Summary</h4> Cancers arise through the acquisition of oncogenic mutations and grow through clonal expansion 1, 2 . Here we reveal that most mutagenic DNA lesions are not resolved as mutations within a single cell-cycle. Instead, DNA lesions segregate unrepaired into daughter cells for multiple cell generations, resulting in the chromosome-scale phasing of subsequent mutations. We characterise this process in...

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Literature Corpus work: 8a79458f-f815-5543-8264-7ca2bfb3cd84
DOI: 10.1101/868679

Open publication

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