Article

Coordinated inheritance of extrachromosomal DNA species in human cancer cells

2023-07-19

Abstract excerpt

<h4>ABSTRACT</h4> The chromosomal theory of inheritance has dominated human genetics, including cancer genetics. Genes on the same chromosome segregate together while genes on different chromosomes assort independently, providing a fundamental tenet of Mendelian inheritance. Extrachromosomal DNA (ecDNA) is a frequent event in cancer that drives oncogene amplification, dysregulated gene expression and intratumoral...

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Literature Corpus work: 6a3b8146-74fa-5deb-947a-d3c910ddf798
DOI: 10.1101/2023.07.18.549597

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