Article

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment

2025-11-16

Abstract excerpt

ecDNA contributes to cancer genetic heterogeneity through random segregation during mitosis. Emerging evidence links ecDNA to immune evasion, but the mechanism remains elusive. Using genetically engineered mouse models of pancreatic ductal adenocarcinoma (PDAC), we show that Kras and Myc oncogenes are amplified either on ecDNAs or as homogeneously staining regions (HSRs) on chromosomes. ecDNA-driven tumors are m...

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Literature Corpus work: 0f3744ef-a18a-5e9f-8d57-ef316e1ea0f3
DOI: 10.1101/2025.11.15.688565

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