Article
Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells
2024-04-21
Abstract excerpt
<h4>ABSTRACT</h4> Extrachromosomal circular DNAs (ecDNA) are focal gene amplifications frequently associated with cancer development and often indicating a poor prognosis. To understand the early dynamics of oncogene-carrying ecDNAs, we previously developed CRISPR-C, a tool for precise ecDNA generation by deleting specific chromosomal regions. Here, we adapted CRISPR-C to recreate tumor ecDNAs. This method also a...
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Identifiers and source
- Literature Corpus work
- 17eeb0dd-9ff9-5f2d-82e1-4adf931460fb
- DOI
- 10.1101/2024.04.18.590030