Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome

27 Apr 2025

Abstract excerpt

Focal amplifications of oncogenes are important cancer drivers. They can occur on chromosomes or in the context of circular extrachromosomal DNA (ecDNA). Many key features of ecDNAs were described in the 1960s to 1980s, including their "unstable" nature and their ability to confer drug resistance. With the benefit of new technologies, our understanding of ecDNAs has advanced dramatically in the last decade, both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40287855
DOI: 10.1158/2159-8290.cd-25-0230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular GenomePMID 40287855Read ↗

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver.Semantic proximity Read ↗

Extrachromosomal circular DNA in cancer: history, current knowledge, and methodsSemantic proximity Read ↗

Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progressionSemantic proximity Read ↗

Extrachromosomal circular DNA: biogenesis, structure, functions and diseasesSemantic proximity Read ↗

Extrachromosomal Circular DNAs: An Extra Piece of Evidence to Depict Tumor HeterogeneitySemantic proximity Read ↗

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer.Semantic proximity Read ↗

Extrachromosomal Circular DNA: A New Target in CancerSemantic proximity Read ↗

Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potentialSemantic proximity Read ↗

Extrachromosomal circular DNA (eccDNA): an emerging star in cancerSemantic proximity Read ↗

Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistanceSemantic proximity Read ↗

eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancersSemantic proximity Read ↗

Extrachromosomal circular DNA in colorectal cancer: biogenesis, function and potential as therapeutic targetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.