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Article

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver.

Science China. Life sciences - 1 Jan 2025

Zhu Huanbo, Huangfu Longtao, Chen Junbing, Ji Jiafu, Xing Xiaofang

Abstract excerpt

Extrachromosomal DNA (ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39349791
DOI: 10.1007/s11427-024-2710-3

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