Article
Extrachromosomal DNA Couples with ATM-mediated DNA Damage Response for Genome Instability in Tumors
2024-01-23
Abstract excerpt
<title>Abstract</title> <p>Extrachromosomal DNA (ecDNA) drives the evolution of cancer cells by conferring survival advantages over normal cells. However, the functional importance of ecDNA replication and maintenance is yet to be evaluated, and the molecular components that contributed to these processes remain largely unknown. Here, using CRISPR-C (circularization of genes and chromosomes by CRISPR) technology...
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Identifiers and source
- Literature Corpus work
- 590341cc-81b6-5bf7-85ac-550058ee1414
- DOI
- 10.21203/rs.3.rs-3708982/v1