Article

Harnessing fusion of genome-edited human stem cells to rapidly screen for novel protein functions <i>in vivo</i>

2025-06-27

Abstract excerpt

Genome editing has enabled the integration of fluorescent protein coding sequences into genomes, resulting in expression of in-frame fusion proteins under the control of their natural gene regulatory sequences. While this technique overcomes the well-documented artifacts associated with gene overexpression, editing genomes of metazoan cells incurs a significant time cost compared to simpler organisms, such as yeas...

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Identifiers and source

Literature Corpus work: 8db52a99-56d9-56bf-b0fe-318e1afcf959
DOI: 10.1101/2025.06.25.661608

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