Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation

Abstract excerpt

<h4>ABSTRACT</h4> Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously “undruggable” proteins. Current degrader molecules primarily target cytosolic substrates, yet nearly one-third of the proteome resides in or transits the endoplasmic reticulum (ER), including receptors, secreted factors, and biosyn...

Topics

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• Endoplasmic Reticulum-Associated Degradation
• Fluorescence
• Glycosylation
• HEK293 Cells
• Luminescent Proteins
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Recombinant Fusion Proteins

Identifiers and source

Literature Corpus work

15692c1e-72e9-5df7-89c5-9ca92803cf52

DOI

10.1101/2025.11.28.691080