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Article

Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation.

Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2013

Grotzke Jeff E, Lu Qiao, Cresswell Peter

Abstract excerpt

Endoplasmic reticulum-associated degradation (ERAD) is a constitutive process that identifies misfolded proteins in the ER and shuttles them to the cytosol, where they can be degraded by the proteasome. The accumulation of misfolded proteins can be catastrophic at both the cellular and organismal level. Although the players involved and mechanistic details of ERAD are being characterized, much remains to be...

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Identifiers

PMID: 23401531
DOI: 10.1073/pnas.1300328110
PMCID: PMC3587246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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