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Article

Identification of an intrinsic determinant critical for maspin subcellular localization and function.

PloS one - 1 Jan 2013

Dzinic Sijana H, Kaplun Alexander, Li Xiaohua, Bernardo Margarida, Meng Yonghong, Dean Ivory, Krass David, Stemmer Paul, Shin Namhee, Lonardo Fulvio, Sheng Shijie

Abstract excerpt

Maspin, a multifaceted tumor suppressor, belongs to the serine protease inhibitor superfamily, but only inhibits serine protease-like enzymes such as histone deacetylase 1 (HDAC1). Maspin is specifically expressed in epithelial cells and it is differentially regulated during tumor progression. A new emerging consensus suggests that a shift in maspin subcellular localization from the nucleus to the cytoplasm...

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Source

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Identifiers

PMID: 24278104
DOI: 10.1371/journal.pone.0074502
PMCID: PMC3837015

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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