Article

Transcriptomic analysis of SEL1L and HRD1 knockout cell lines reveals multifaceted roles of SEL1L beyond the ER quality control

2024-06-12

Abstract excerpt

<title>Abstract</title> The endoplasmic reticulum (ER) orchestrates major cellular processes, including protein synthesis, folding, assembly and degradation, to maintain cellular proteostasis. Central to these processes are highly stringent quality control machineries like the ER-associated protein degradation (ERAD). Key players in ERAD include HRD1 and SEL1L, which target misfolded proteins for ubiquitinatio...

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Literature Corpus work: 5c07da75-48c9-50c5-b4ea-60072268f702
DOI: 10.21203/rs.3.rs-4484044/v1

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