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Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies

2026-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Glycoprotein nonmetastatic melanoma B (GPNMB), encoded by the target gene ( GPNMB ) of a Parkinson’s disease (PD) risk locus, acts as a secreted factor mediating inflammatory effects in the context of immunity and cancer. In a neurodegenerative disease context, GPNMB is critical to cellular uptake of pathological forms of alpha-synuclein (aSyn), the hallmark disease protein that misfolds and ac...

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Literature Corpus work
5f21e574-13b2-5d5d-9b66-a7f8429ea929
DOI
10.64898/2026.01.26.26344888
Open publication

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Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodiesDOI 10.64898/2026.01.26.26344888
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