Article

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

2026-02-03

Abstract excerpt

<title>Abstract</title> <p> Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading genetic cause of familial FTD, disrupts lysosomal function, lipid metabolism, autophagy, and neuroimmune signaling across multiple cell types. Increasing evidence indicates that microglia ar...

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Literature Corpus work: 4eb9c964-1b14-5997-9ccd-f2b3829e7f1d
DOI: 10.21203/rs.3.rs-8603227/v1

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