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Signatures of glial activity can be detected in the CSF proteome

6 Jun 2022

Abstract excerpt

Single-cell transcriptomics has revealed specific glial activation states associated with the pathogenesis of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease. While these findings may eventually lead to new therapeutic opportunities, little is known about how these glial responses are reflected by biomarker changes in bodily fluids. Such knowledge, however, appears crucial for patient...

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PMID: 35666874
DOI: 10.1073/pnas.2119804119

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