Article

MerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microglia

2023-03-05

Abstract excerpt

MerTK is a receptor tyrosine kinase that mediates the immunologically silent phagocytic uptake of diverse types of cellular debris. Highly expressed on the surface of microglial cell, MerTK is of importance in brain development, homeostasis, plasticity, and disease. Yet, involvement of this receptor in the clearance of protein aggregates that accumulate with aging and in neurodegenerative diseases has yet to be de...

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Literature Corpus work: 0b78f811-8df7-5634-96e2-a7fb55bbd32b
DOI: 10.1101/2023.03.04.531108

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