Article

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

2026-01-13

Abstract excerpt

Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading genetic cause of familial FTD, disrupts lysosomal function, lipid metabolism, autophagy, and neuroimmune signaling across multiple cell types. Increasing evidence indicates that microglia are particularly sensitive to pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 006ecd77-5eef-50eb-82d4-43684cc09c07
DOI: 10.64898/2026.01.13.699312

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient MiceDOI 10.64898/2026.01.13.699312Read

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient MiceSemantic proximity Read

Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotectionSemantic proximity Read

Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cellsSemantic proximity Read

Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microgliaSemantic proximity Read

An Integrated Neuroimmune Assembloid Model to Advance Neurodegenerative Disease StudiesSemantic proximity Read

Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative diseaseSemantic proximity Read

Multiomic profiling reveals aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microgliaSemantic proximity Read

A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microgliaSemantic proximity Read

Transplantation of wild-type hematopoietic stem and progenitor cells rescue Alzheimer’s disease in a mouse model and highlights the central role of microglia in disease pathogenesisSemantic proximity Read

Functional Mature Human Microglia Developed in Human iPSC Microglial Chimeric Mouse BrainSemantic proximity Read

Aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia.Semantic proximity Read

Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal modelSemantic proximity Read