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Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk

4 Oct 2021

Abstract excerpt

Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions. Although the activity of the protein has been extensively studied in neurons, the protein is also expressed in other cell types including immune cells and glia. Genetic studies show that mutations in...

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PMID: 34671245
DOI: 10.3389/fncel.2021.759571

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