Article

Microglial Lag3 Drives α-Synuclein–induced Neurotoxic Activated (A1) Astrocytes and Neurodegeneration

2026-01-06

Abstract excerpt

<h4>Background</h4> Neuroinflammation and pathologic α-synuclein (α-syn) aggregation cooperate to drive dopaminergic neurodegeneration in Parkinson’s disease, but the glial receptors that couple extracellular α-syn to inflammatory cascades remain incompletely defined. Microglia express higher levels of lymphocyte activation gene 3 (Lag3) than neurons, yet the contribution of microglial Lag3 to α-syn recognition,...

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Literature Corpus work: ff4ad387-8cb0-539f-966f-38f1b9dd94dc
DOI: 10.64898/2026.01.06.697996

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