GPNMB confers risk for Parkinson's disease through interaction with α-synuclein.

doi:10.1126/science.abk0637

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Article

GPNMB confers risk for Parkinson's disease through interaction with α-synuclein.

Science (New York, N.Y.) - 19 Aug 2022

Diaz-Ortiz Maria E, Seo Yunji, Posavi Marijan, Carceles Cordon Marc, Clark Elisia, Jain Nimansha, Charan Rakshita, Gallagher Michael D, Unger Travis L, Amari Noor, Skrinak R Tyler, Davila-Rivera Roseanne, Brody Eliza M, Han Noah, Zack Rebecca, Van Deerlin Vivianna M, Tropea Thomas F, Luk Kelvin C, Lee Edward B, Weintraub Daniel, Chen-Plotkin Alice S

Abstract excerpt

Many risk loci for Parkinson's disease (PD) have been identified by genome-wide association studies (GWASs), but target genes and mechanisms remain largely unknown. We linked the GWAS-derived chromosome 7 locus (sentinel single-nucleotide polymorphism rs199347) to GPNMB through colocalization analyses of expression quantitative trait locus and PD risk signals, confirmed by allele-specific expression studies in...

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Identifiers

PMID: 35981040
DOI: 10.1126/science.abk0637
PMCID: PMC9870036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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