Article

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis

2025-01-01

Abstract excerpt

Genome-wide association studies have identified Glycoprotein Nmb ( GPNMB ) as a risk factor for Parkinson’s Disease. The risk allele increases GPNMB transcription and GPNMB protein levels in the CSF highlighting GPMNB as a potential biomarker for Parkinson’s Disease. However, a lack of knowledge of GPNMB’s function and mechanism of secretion have hindered an interpretation of secreted GPNMB levels. In this stud...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2b46f37-eb6c-5d58-9550-52bb57506d4d
DOI: 10.1101/2025.01.01.630988

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosisDOI 10.1101/2025.01.01.630988Read

GPNMB, LRRK2, and lysosome exocytosis in Parkinson's.Semantic proximity Read

Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkersSemantic proximity Read

Transcriptome deregulation of peripheral monocytes in <i>GBA</i>-related Parkinson’s diseaseSemantic proximity Read

Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodiesSemantic proximity Read

Integrated Biofluid Proteomics Identified Dynamic Functional Biomarkers of <i>LRRK2</i> -Linked Parkinson’s Disease ProgressionSemantic proximity Read

LRP10 as a novel α-synuclein regulator in Lewy body diseasesSemantic proximity Read

Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation and inflammationSemantic proximity Read

Lysosomes cell autonomously regulate myeloid cell states and immune responsesSemantic proximity Read

Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2Semantic proximity Read

PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseasesSemantic proximity Read

A Common PD-Risk <i>GBA1</i> Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial DysfunctionSemantic proximity Read

Integrated Stress Response Signatures Drive Monocyte Dysfunction in GBA1- and LRRK2-Linked Parkinson’s DiseaseSemantic proximity Read