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Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion Disease

2025-02-12

Abstract excerpt

Neurodegenerative conditions can induce the region-specific emergence of cell states relevant to their pathogenesis. To identify such phenomena, we generated a spatiotemporal transcriptomic atlas of mice infected with the RML prion strain. Thalamus and cerebellum experienced severe neuronal loss, developed intense microgliosis and, starting from 30 weeks post-inoculation, accumulated a novel microglial subpopulati...

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Literature Corpus work
358f859c-dd3c-53e5-beb4-e3f317ead187
DOI
10.1101/2025.02.11.637592
Open publication

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Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion DiseaseDOI 10.1101/2025.02.11.637592
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