Article

Age-related nigral downregulation of the Parkinson’s risk factor FAM49B primes human microglia for inflammaging

2025-07-18

Abstract excerpt

<title>Abstract</title> <p> Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), which is associated with changes in microglia function. While age remains the biggest risk factor, the underlying molecular cause of PD onset and its concurrent neuroinflammation are not well understood. Many identified PD risk genes have been directly linked to...

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Literature Corpus work: e3d62174-55a7-5426-8d56-ee40a728ffad
DOI: 10.21203/rs.3.rs-6925731/v1

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