Article

A comprehensive catalog of 3D genome organization in diverse human genomes facilitates understanding of the impact of structural variation on chromatin structure

2023-05-15

Abstract excerpt

<h4>Summary</h4> The human genome is packaged into the three-dimensional (3D) nucleus and organized into functional units known as topologically associating domains (TADs) and chromatin loops. Recent studies show that the 3D genome can be modified by genome structural variants (SVs) through disrupting higher-order chromatin organizations such as TADs, which play an essential role in insulating genes from aberrant...

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Literature Corpus work: 5a226086-a167-50e2-923f-8c6a40ee4ace
DOI: 10.1101/2023.05.15.540856

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