Article
Handling realistic assumptions in hypothesis testing of 3D co-localization of genomic elements.
Nucleic acids research - 1 May 2013
Paulsen Jonas, Lien Tonje G, Sandve Geir Kjetil, Holden Lars, Borgan Ornulf, Glad Ingrid K, Hovig Eivind
Abstract excerpt
The study of chromatin 3D structure has recently gained much focus owing to novel techniques for detecting genome-wide chromatin contacts using next-generation sequencing. A deeper understanding of the architecture of the DNA inside the nucleus is crucial for gaining insight into fundamental processes such as transcriptional regulation, genome dynamics and genome stability. Chromatin conformation capture-based...
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