Article

Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis

2025-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Host immunity in sepsis has features of hyperinflammation together with progressive immunosuppression, particularly among CD4 T cells, that can predispose to secondary infections and ineffectual organ recovery. Metabolic and immunologic dysfunction are archetypal findings in critically ill patients with sepsis, but whether these factors are mechanistically linked remains incompletely defined. We...

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Literature Corpus work: 4ef3c491-a750-52b9-a599-bfc98d644f9b
DOI: 10.1101/2025.01.27.635146

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