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Cellular metabolism regulates the differentiation and function of T-cell subsets

2 Apr 2024

Abstract excerpt

T cells are an important component of adaptive immunity and protect the host from infectious diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune disorders. In both situations, antigen-specific T cells undergo clonal expansion upon the engagement and activation of antigens. Cellular metabolism is reprogrammed to meet the increase in bioenergetic and biosynthetic demands associated with...

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PMID: 38565887
DOI: 10.1038/s41423-024-01148-8

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