Article

TNFR2 costimulation differentially impacts regulatory and conventional CD4 <sup>+</sup> T-cell metabolism

2022-03-27

Abstract excerpt

CD4 + conventional T cells (Tconvs) mediate adaptive immune responses, whereas regulatory T cells (Tregs) suppress those responses to safeguard the body from autoimmunity and inflammatory diseases. The opposing activities of Tconvs and Tregs depend on the stage of the immune response and their environment, with an orchestrating role for cytokine- and costimulatory receptors. Nutrient availability also impacts T-c...

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Literature Corpus work: eb53812c-542a-52de-8730-8000157afc33
DOI: 10.1101/2022.03.25.485786

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