Article

HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells

2023-10-19

Abstract excerpt

<h4>Background</h4> Cholesterol-loading of mouse aortic vascular smooth muscle cells (mVSMCs) downregulates miR-143/145 , a master regulator of the contractile state downstream of TGFβ signaling. In vitro, this results in transitioning from a contractile mVSMC to a macrophage-like state. This process likely occurs in vivo based on studies in mouse and human atherosclerotic plaques. <h4>Objectives</h4> To tes...

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Literature Corpus work: 5cb9bcce-00b1-581d-9fea-51e2443151d2
DOI: 10.1101/2023.10.19.562786

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