Article
Cholesterol loading reprograms the microRNA-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2015
Vengrenyuk Yuliya, Nishi Hitoo, Long Xiaochun, Ouimet Mireille, Savji Nazir, Martinez Fernando O, Cassella Courtney P, Moore Kathryn J, Ramsey Stephen A, Miano Joseph M, Fisher Edward A
Abstract excerpt
OBJECTIVE: We previously showed that cholesterol loading in vitro converts mouse aortic vascular smooth muscle cells (VSMC) from a contractile state to one resembling macrophages. In human and mouse atherosclerotic plaques, it has become appreciated that ≈40% of cells classified as macrophages by histological markers may be of VSMC origin. Therefore, we sought to gain insight into the molecular regulation of this...
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