Article

Smooth Muscle Cell-Specific TGFβ2 Protects Against Thoracic Aortic Aneurysm and Dissection in Mice

2025-10-03

Abstract excerpt

<h4>Objective</h4> Thoracic aortic aneurysm and dissection (TAAD) are major complications of Loeys- Dietz syndrome caused by heterozygous TGFB2 mutations. While Tgfb2 knockout mice die at birth and adult heterozygotes develop late, non-dissecting or non-rupturing aneurysms, the role of vascular smooth muscle cell (SMC)–derived TGFβ2 in postnatal aortic homeostasis and disease remains undefined. <h4>Approach an...

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Literature Corpus work: a452e53c-6a2b-5eb3-add5-b45e90e6fa32
DOI: 10.1101/2025.10.01.679917

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