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Article

Smooth muscle cell phenotypic modulation during atherosclerosis.

Vascular pharmacology - 1 Mar 2026

Frausto Louise, Scott Matthew L, Orr A Wayne, Yurdagul Arif

Abstract excerpt

Vascular smooth muscle cells (vSMCs) play a central role in atherosclerotic plaque development and stability through their remarkable phenotypic plasticity. In healthy vessels, contractile vSMCs maintain vascular tone and structural integrity. During atherogenesis, lipid accumulation, inflammatory cues, growth factors, and mechanical stress drive vSMC dedifferentiation, proliferation, and migration into the...

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Share to Cell Plasticity
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

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Source

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Identifiers

PMID: 41349733
DOI: 10.1016/j.vph.2025.107570
PMCID: PMC13047746

Genes

KLF4
SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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