Article

Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of Low Density Lipoprotein Related Protein 1 (LRP1)

2021-12-01

Abstract excerpt

<h4>Objective</h4> Atherosclerosis is a progressive, degenerative vascular disease and a leading cause of morbidity and mortality. In response to endothelial damage, platelet derived growth factor (PDGF)-BB induced phenotypic modulation of medial smooth muscle cells (VSMCs) promotes atherosclerotic lesion formation and destabilisation of the vessel wall. VSMC sensitivity to PDGF-BB is determined by endocytosis of...

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Literature Corpus work: 368bd8f9-977a-5722-a9a7-226a6e4991e5
DOI: 10.1101/2021.11.30.470548

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