Article
Myocardin regulates vascular smooth muscle cell inflammatory activation and disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2015
Ackers-Johnson Matthew, Talasila Amarnath, Sage Andrew P, Long Xiaochun, Bot Ilze, Morrell Nicholas W, Bennett Martin R, Miano Joseph M, Sinha Sanjay
Abstract excerpt
OBJECTIVE: Atherosclerosis, the cause of 50% of deaths in westernized societies, is widely regarded as a chronic vascular inflammatory disease. Vascular smooth muscle cell (VSMC) inflammatory activation in response to local proinflammatory stimuli contributes to disease progression and is a pervasive feature in developing atherosclerotic plaques. Therefore, it is of considerable therapeutic importance to identify...
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