Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-145 micelles mitigate atherosclerosis by modulating vascular smooth muscle cell phenotype.

Biomaterials - 1 Jun 2021

Chin Deborah D, Poon Christopher, Wang Jonathan, Joo Johan, Ong Victor, Jiang Zhangjingyi, Cheng Kayley, Plotkin Anastasia, Magee Gregory A, Chung Eun Ji

Abstract excerpt

In atherosclerosis, resident vascular smooth muscle cells (VSMCs) in the blood vessels become highly plastic and undergo phenotypic switching from the quiescent, contractile phenotype to the migratory and proliferative, synthetic phenotype. Additionally, recent VSMC lineage-tracing mouse models of atherosclerosis have found that VSMCs transdifferentiate into macrophage-like and osteochondrogenic cells and make up...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Micelles

Share to MicroRNAs

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Source

Open in PubMed Open full text

Identifiers

PMID: 33892346
DOI: 10.1016/j.biomaterials.2021.120810
PMCID: PMC8152375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-145 micelles mitigate atherosclerosis by modulating vascular smooth muscle cell phenotype.PMID 33892346Read ↗

Nanoparticle-mediated microRNA-145 Delivery for Vascular Smooth Muscle Cell Phenotype Modulation and Atherosclerosis TreatmentSemantic proximity Read ↗

Cholesterol loading reprograms the microRNA-143/145-myocardin axis to convert aortic smooth muscle cells to a dysfunctional macrophage-like phenotype.Semantic proximity Read ↗

Phenotypic switching of vascular smooth muscle cells in the 'normal region' of aorta from atherosclerosis patients is regulated by miR-145.Semantic proximity Read ↗

MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.Semantic proximity Read ↗

Targeting VSMCs to suppress macrophage-like phenotype switching that restrains atherogenesis by immunosuppressive oligodeoxynucleotide (A151) functionalized selenium nanoparticles.Semantic proximity Read ↗

HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cellsSemantic proximity Read ↗

CD146 extracellular vesicles accumulate at atherosclerotic lesions, reducing inflammation and atheroma burden.Semantic proximity Read ↗

miR-146a-5p mediates atherogenic signalling from immune to vascular cells.Semantic proximity Read ↗

MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice.Semantic proximity Read ↗

MicroRNA-145 restores contractile vascular smooth muscle phenotype and coronary collateral growth in the metabolic syndrome.Semantic proximity Read ↗

Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster.Semantic proximity Read ↗

MicroRNA-modulated targeting of vascular smooth muscle cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.