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Article

Cholesterol-Induced Phenotypic Modulation of Smooth Muscle Cells to Macrophage/Fibroblast-like Cells Is Driven by an Unfolded Protein Response.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2021

Chattopadhyay Abhijnan, Kwartler Callie S, Kaw Kaveeta, Li Yanming, Kaw Anita, Chen Jiyuan, LeMaire Scott A, Shen Ying H, Milewicz Dianna M

Abstract excerpt

OBJECTIVE: Vascular smooth muscle cells (SMCs) dedifferentiate and initiate expression of macrophage markers with cholesterol exposure. This phenotypic switching is dependent on the transcription factor Klf4 (Krüppel-like factor 4). We investigated the molecular pathway by which cholesterol induces SMC phenotypic switching. Approach and Results: With exposure to free cholesterol, SMCs decrease expression of...

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Identifiers

PMID: 33028096
DOI: 10.1161/ATVBAHA.120.315164
PMCID: PMC7752246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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