Article

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture

2026-01-29

Abstract excerpt

To probe drug mechanism of action (MOA) and interrogate the genetic architecture of human cells, we carried out isogenic genome-wide CRISPR/Cas9 knockout screens against 310 diverse drugs, bioactive compounds, and stress conditions. Stringent statistical correction for gene knockout fitness defects yielded a large-scale matrix of >12,000 high confidence chemical-genetic interactions (CGIs). This dataset revealed m...

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Literature Corpus work: f970caa5-bfb1-51e3-a86c-db943d50ef37
DOI: 10.64898/2026.01.28.701823

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